Benchmark indices started off trade on a weak note after investors digested US Federal Reserve's rate hike.
The 30-share BSE Sensex fell 93.70 points to 35,645.46 and the 50-share NSE Nifty declined 35.30 points to 10,821.40.
Infosys lost 2 percent.
Vedanta, BPCL, HPCL, IOC, SBI, Axis Bank, ICICI Bank and Tata Steel are under pressure.
Lupin, Cipla, Aurobindo, Bharti Airtel and HDFC Bank are early gainers.
Nifty Midcap index dropped 36 points and Nifty Bank slipped 70 points.
Dish TV, Vakrangee, Granules India, gained up to 5 percent.
NBCC, Shree Renuka, Bhansali Engineering, Oberoi Realty, Mindtree, Future Consumer, SBI Life, Adani Power, Suzlon, Reliance Power, Canara Bank, PNB, Gammon Infra, Videocon and GMR Infrastructure declined up to 5 percent.
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